Limited Sampling Strategies for Predicting Tacrolimus Systemic Exposure After Adult Kidney Transplantation: A Narrative Review.
BACKGROUND After kidney transplantation, therapeutic drug monitoring (TDM) of tacrolimus (Tac) relies mainly on the predose concentration (C0). However, C0 has limited ability to accurately reflect systemic Tac exposure. The area under the concentration-time curve (AUC) provides a more comprehensive measure of total sy...