Author

Cédric Peirs

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Open access Sep 2026

Sensory plasticity of dorsal horn silent neurons as a critical mechanism for neuropathic pain

The spinal cord dorsal horn (DH) integrates sensory processing but undergoes critical plasticity following nerve injury, leading to mechanical allodynia, or “touch-evoked pain”. It has been proposed that after nerve injury, innocuous sensory neurons gain access to nociceptive-specific (NS) circuits in the DH due to alt...

Ahmed Negm, François Gabrielli, Mickaël Zbili et al. · Nature Communications · 0 citations

Open access Sep 2026

A molecular and spinal circuit basis for the functional segregation of itch and pain

Summary The dorsal horn is remarkably diverse, yet how this cellular complexity enables discrimination of sensory modalities remains a fundamental question. Neurons expressing gastrin-releasing peptide receptor (Grpr+) have long been considered dedicated to itch, yet broad activation also evokes pain-related behavior....

M. Noh, Kelly A. Corrigan, Sean-Paul G. Williams et al. · Neuron · 0 citations