Cognitive changes in the asymptomatic stages of Alzheimer disease (AD) are subtle and difficult to detect using conventional cognitive tests. High‐frequency smartphone‐based testing may improve sensitivity to these changes, but generational differences in technology use could influence performance. We examined generati...
Samhita Katteri, Hannah M. Wilks, Matthew S. Welhaf et al.· Alzheimer's & Dementia· 0 citations
Summary The apolipoprotein E ε4 (APOE4) allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD), yet the mechanistic underpinnings by which it alters human microglial function remain poorly understood. Here, we utilize CRISPR/Cas9-engineered isogenic human induced pluripotent stem cell-deriv...
Y. You, Son N. Nguyen, Sean D. Mann et al.· Research Square· 0 citations
The results demonstrate that C4 may have functions beyond the classical complement cascade and may serve as a key facilitator of AD-related glial function and pathology and a possible target for therapeutic modification.
C. Nadarajah, Michelle Y. Li, Sohui Park et al.· bioRxiv· 0 citations
Using isogenic human induced pluripotent stem cell-derived microglia carrying the pathogenic MAPT IVS10+16 mutation, tau is identified as a regulator of microglial lysosomal function and degradative capacity is identified as a modifiable component of the microglial response to tau pathology.
Kylie J. Schache, Rui Zhang, Audrey Street et al.· bioRxiv· 0 citations
These findings identify Ms4a4a as a regulator of plaque-associated microglial programs linked to NP-tau accumulation in the amyloid-bearing brain, which supports a model in which AD resilience-associated microglial pathways selectively shape plaque-associated microenvironments that promote downstream tau pathology.
E. Danhash, Shao-Yu Fang, Jacob A. Marsh et al.· bioRxiv· 0 citations
Findings identify widespread lncRNA dysregulation across neural cell types in the setting of a MAPT mutation and nominate the NORAD-pumilio axis as a regulatory pathway linking RNA homeostasis and tau propagation biology.
Joseph E. Zemke, Guangming Huang, Emma Starr et al.· bioRxiv· 0 citations
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