Author

Celia M. Santi

2 papers indexed here

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Open access Oct 2026

A histidine-mediated supramolecular mechanism links temperature and pH activation of the sperm channel CatSper.

The cation channel of sperm, CatSper, is a sperm-specific calcium channel essential for male fertility across metazoans. CatSper is activated by intracellular alkalinization, membrane depolarization, and elevated temperature, which together ensure maximal current generation. However, the structural mechanisms by which...

Billy Zhao, Shweta Bhagwat, Juan Ferreira et al. · PLoS Biology · 0 citations

Open access Sep 2026

Sperm development requires TMC5-dependent mechanoresponsive calcium entry

Spermiogenesis, the transformation of round spermatids into streamlined, fertilization-competent sperm, represents cellular morphogenesis at its most extreme1,2. Despite decades of effort, spermiogenesis remains difficult to recapitulate outside the testis2,3, highlighting the importance of cues within the native tissu...

Wenhao Zheng, Lorena Roa-de la Cruz, John Duncan et al. · bioRxiv · 0 citations