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Author

C. Verheggen

2 papers indexed here

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Sep 2026

The early RNA decay factor ZC3H18 directs first intron splicing.

Pre-mRNA splicing is essential for gene expression. In human cells, the cap-binding complex (CBC) has long been known to facilitate first intron splicing, but it is by an unknown mechanism. The CBC also promotes early RNA decay by recruiting the nuclear exosome targeting (NEXT) complex via the linker proteins ARS2 and...

Marion Le Rest, Nour el Houda Benbahouche, Christopher C. Kuhn et al. · 0 citations
Open access Jul 2026

A large-scale analysis of the R2TP chaperone network reveals its contribution to the assembly of INO80, SRCAP and TIP60

HSP90/R2TP is an essential quaternary chaperone composed of RPAP3, PIH1D1 and the RUVBL1/RUVBL2 AAA+ ATPases. These enzymes are also part of the INO80, SRCAP and TIP60 complexes, but the relationship between these chromatin remodelers and R2TP remains unclear. Here, we performed systematic analyses of the R2TP-specific...

Y. Abel, Manon Philippe, Laurence Decourty et al. · 0 citations

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