2026
The Open Conformation of CCT: How to Achieve High Resolution Using CryoEM.
Jorge Gutiérrez-Seijo, César Santiago, Sergio Pipaón et al.
· Methods in molecular biology · 0 citations
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2026
CryoEM Strategies for Elucidating the Closed State Architecture of CCT.
This study investigates the eukaryotic chaperonin CCT, a ~1 MDa hetero-oligomeric complex essential for the folding of key substrates such as actin, tubulin, and WD40 family members and demonstrates that subunit assignment and atomic modeling are achievable by exploiting subunit-intrinsic structural features alone.
Jorge Gutiérrez-Seijo, Ana Cuervo, Sergio Pipaón et al.
· Methods in molecular biology · 0 citations
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Jul 2026
Pre-existing and Cross-Reactive Immunity to Avian Influenza H5N1 in Humans: Implications for Pandemic Risk and Vaccine Strategies.
Current evidence on cross-reactive and cross-protective immunity to H5N1 in humans, focusing primarily on humoral immune responses is summarized, and particular attention is given to antibodies targeting conserved regions of hemagglutinin (HA) as well as neuraminidase (NA), which may provide heterosubtypic protection.
Iván Sanz-Muñoz, Carlos J. Ciria-Gil, Marta Hernández et al.
· Journal of Infection · 0 citations