BOX–BEHNKEN DESIGN APPROACH FOR OPTIMIZATION OF ACECLOFENC LOADED TRANSFEROSOMAL GEL FOR ENHANCED TRANSDERMAL DELIVERY
Objective: The current study aimed to develop and optimize an aceclofenac (ACF)-loaded transferosomal gel for transdermal drug delivery using a Box–Behnken design (BBD), thereby enhancing bioavailability and reducing systemic side effects. Methods: Using different ratios of Span 80 and phosphatidylcholine (PDC), transf...