Open access
Aug 2026
A Molecular Mechanistic Deep Dive into 14-3-3 Molecular Glue Cooperativity.
Molecular glues (MGs) stabilize protein-protein interactions (PPIs) through interactions at composite binding interfaces, thereby promoting cooperative ternary complex formation. For hub proteins that engage in multiple PPIs with widely varying intrinsic affinities, the interplay between binary PPI affinity and MG coop...
Marloes A. M. Pennings, Edmee M. F. Vandenboorn-Bönner, Lisa Nooren et al.
· Biochemistry · 0 citations