Chaluvaraju K. C.

Design, synthesis, and preliminary antiproliferative evaluation of azetidine-functionalized pyrrolo[2,3-d]pyrimidines with integrated computational studies.

Azetidine-functionalized pyrrolo[2,3-d]pyrimidines were designed to examine the comparative influence of methyl-, propyl-, and butylsulfonyl substitution among final synthesized analogues on antiproliferative activity and structure-based behavior. Following in silico ADME filtering and docking-based prioritization, sel...