Abstract B010: RUNX1/2-mediated chromatin accessibility governs the activation of cancer associated fibroblasts in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) remains the deadliest cancer with only 13% of five-year survival rate in patients. However, effective drug delivery and administration of immunotherapy have been limited due to the dense fibrotic stroma in PDAC tumor microenvironment, majorly contributed by cancer-associated fi...