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Author

Chang-Jiang Dong

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Open access Sep 2026

PAXIP1-PAGR1 directs cohesin recruitment during break-induced telomere repair

Cohesin is a conserved multiprotein complex (SMC1, SMC3, RAD21, and either STAG1 or STAG2) that organizes three-dimensional genome architecture and regulates chromosome segregation, gene expression, and DNA damage repair1–4. Following double-strand breaks (DSBs), cohesin is recruited to sites of DNA damage - a process...

S. Hwang, Xiao-Ying Wu, Xian-Gao Huang et al. · 0 citations
Jul 2026

Structural, functional, and mechanistic studies of the bacterial divisome FtsWIQBL in complex with antibiotics.

Cryo-electron microscopy structures and genetic and biochemical analyses reveal the mechanism of FtsQBLWI-controlled sPG synthesis and β-lactam action on this complex, providing a molecular basis for optimizing existing β-lactams and developing novel antibiotics.

Shimin Zhu, Yan-Jie Hu, Rong Wang et al. · 0 citations

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