We report the results from a Phase 1 study (NCT04557150) evaluating subcutaneous (SC) forimtamig, a novel GPRC5DxCD3 bispecific antibody with a 2:1 configuration, in relapsed/refractory multiple myeloma (RRMM). After dose-escalation, backfilling at optimized target doses in combination with weekly (step-up: Cycle [C] 1...
Anna Caroline Hasselbalch, Simon J. Harrison, Salomon Manier et al.· Blood Advances· 0 citations
Background Blinatumomab, a bispecific T-cell engager, mediates cytotoxicity through CD3+ T-cell activation and has shown efficacy in relapsed or refractory (R/R) B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Although T-cell expansion correlates with favorable outcomes, routine immunophenotyping is impractica...
Seonghan Lee, Daehun Kwag, G. Min et al.· Therapeutic Advances in Hema...· 0 citations
To the Editor: Relapse after allogeneic hematopoietic cell transplantation (allo-HCT) remains one of the most challenging events in adult acute lymphoblastic leukemia (ALL) and a leading cause of treatment failure [1, 2]. Second allo-HCT has historically been regarded as the only potentially curative option for patient...
Jaehyun Ahn, Daehun Kwag, G. Min et al.· Blood Cancer Journal· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.