Chang-Kun Huang

Integrated toxicogenomic and single-nucleus transcriptomic analyses prioritize SDHB and NDUFAB1 in mitochondrial respiration-associated remodeling during cisplatin-induced acute kidney injury

Cisplatin-induced acute kidney injury (Cis-AKI) is a multifactorial nephrotoxic syndrome involving proximal tubular injury, oxidative and inflammatory stress, mitochondrial dysfunction, metabolic disturbance, and regulated cell death. However, the molecular targets linking cisplatin-associated toxicogenomic changes...