Open access
Sep 2026
Targeting the AKT2-NAMPT phosphorylation axis prevents macrophage senescence to enhance bactericidal activity in septic immunosuppression.
A dual-layer regulatory mechanism in which DDX6 controls NAMPT abundance, whereas AKT2 dictates its activity drives senescence during immune tolerance is identified, identifying AKT2-NAMPT as a potential therapeutic axis to restore immune competence in sepsis.
Qi-Lan Li, Mei He, Pei-Lin Shi et al.
· International Immunopharmaco... · 0 citations