Chang-Lian Zhu

Neonatal inflammation disrupts a temporally restricted postnatal Numb-enriched microglial state in mice

Early-life microglia are diverse and support brain development beyond immune surveillance, but the transient states associated with postnatal maturation remain poorly understood. Here we show, using a time-resolved single-cell atlas of neonatal mouse brain immune cells, that a postnatal Numb-enriched microglial state e...