Open access
Aug 2026
Quantitative proteomic analysis of the anti-ferroptosis effect of a proprietary hydroxy-α-sanshool extract in human keratinocytes using a tandem mass tag labeling approach
Hydroxy-α-sanshool (HAS), a bioactive alkylamide from Sichuan peppercorns, is known for its antioxidant and neurosensory properties, yet the molecular mechanism underlying its skin-protective effects remains unclear. Herein, we report that HAS alleviates RSL-3-induced ferroptosis in human keratinocytes by restoring cel...
Huifang Li, Xian Jiang, Ang Cai et al.
· RSC Advances · 0 citations