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Chang-Sheng Chen

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Review Open access Sep 2026

INPP5D/SHIP1 in Alzheimer’s Disease: Linking Microglial Substrate Handling to Neuroinflammation and Neurovascular Dysfunction

INPP5D, which encodes Src homology 2 domain-containing inositol 5-phosphatase 1 (SHIP1), has emerged as an Alzheimer’s disease (AD)-associated gene with strong links to microglial biology. As a hematopoietic-enriched lipid phosphatase, SHIP1 converts phosphatidylinositol-3,4,5-trisphosphate to phosphatidylinositol-3,4-...

Jun-Xiang Xu, Yi-Jin Chang, Dong Liu et al. · 0 citations

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