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Author

Chang-Tai Luo

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2 papers indexed here

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Open access Oct 2026

Combining network toxicology with in vitro and in vivo experimental validation to investigate the toxicological mechanisms of phthalate exposure in promoting osteosarcoma.

Phthalates (PAEs), as ubiquitous persistent organic pollutants and typical endocrine disruptors (EDCs), have been shown in epidemiological studies to be associated with the development of osteosarcoma (OS). However, the molecular mechanisms by which PAEs regulate the occurrence and progression of OS remain unclear. Acc...

Hai-Dong Zhou, Hai-Yang Wang, Jun-Xiu Zhou et al. · 0 citations
Open access Sep 2026

Myocardial senescence as a mechanistic endpoint of arsenic cardiotoxicity: Cysteine-associated p53/p21 activation and reversal by quercetin.

This study investigates how environmental arsenic exposure induces cardiotoxicity via myocardial senescence by in vivo/in vitro models and evaluates the protective effects of quercetin. In vivo, 3-week-old male C57BL/6 mice were exposed to sodium arsenite (NaAsO2) in drinking water at 10 or 20 mg/L for 6 weeks, with 22...

Hao-Guo Wang, Yi-Ying Wang, Si-Yuan Huang et al. · 0 citations

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