Open access
Jul 2026
Baseline plasma C1q and C3 as potential biomarkers for lecanemab efficacy and ARIA risk in early Alzheimer's disease
Abstract INTRODUCTION The classical complement cascade has been implicated in amyloid beta (Aβ) clearance and in the pathogenesis of amyloid‐related imaging abnormalities (ARIA) during anti‐amyloid monoclonal antibody therapy. Clinically accessible peripheral biomarkers of this cascade remain uncharacterized in real‐wo...
Gihwan Byeon, Jung-Won Lee, Suhyung Kim et al.
· Alzheimer's & Dementia · 0 citations