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Author

Changbin Pan

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Sep 2026

METTL15-mediated m4C modification regulates glucose metabolic reprogramming via c-Myc-dependent mechanisms and promotes hepatocellular carcinoma progression.

Although aerobic glycolysis is a hallmark of hepatocellular carcinoma (HCC) progression, the underlying epitranscriptomic mechanisms remain poorly understood. Here, we identify METTL15, an N4-methylcytidine (m4C) RNA methyltransferase, as a novel oncogenic driver of this metabolic reprogramming. METTL15 is significantl...

Longhui Xie, Ken Ning, Yu-Hu Wang et al. · 0 citations

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