Changkyu Lee

PIANO: Probabilistic Inference Autoencoder Networks for multi-Omics enables robust generative modeling of gene expression and scales single-cell integration to 100 million cells

PIANO accurately integrates single-cell data across species and across single-cell and spatial transcriptomics modalities and models spatially-resolved gene expression during Alzheimer’s disease progression in human brains and integrates over 100 million cancer cells to model drug perturbations.