MARCH8 inhibits PRRSV-2 replication by targeting viral GP5 for proteasomal degradation at a conserved lysine 163.
Porcine reproductive and respiratory syndrome virus (PRRSV) continues to pose a significant threat to global swine production. In China, PRRSV type 2 (PRRSV-2) is the predominant strain, and the inadequate cross-protection provided by existing vaccines highlights the urgent need for novel antiviral agents capable of ef...