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Chantal Lucini

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Open access Oct 2026

Exploring the potential of vamotinib in Ph+ leukemias: is it indeed a 3rd generation tyrosine kinase-inhibitor?

The development of tyrosine kinase inhibitors (TKIs) has markedly improved outcomes in Philadelphia chromosome–positive leukemias; however, resistance mediated by BCR::ABL1 kinase domain (KD) mutations remains a major challenge. While the third-generation TKIs ponatinib and asciminib can suppress many resistant mutatio...

Chantal Lucini, Isabella Sponseiler, Anna-Maria Bandian et al. · 0 citations

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