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Chanyah M. Wood

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Review Open access Aug 2026

Targeting ADAR1 in Cancer: Biology, Therapeutic Strategies, Challenges, and Limitations

Adenosine deaminase acting on RNA 1 (ADAR1) is a critical regulator of innate immune signaling and a pan-cancer therapeutic target. Through catalyzing adenosine-to-inosine (A-to-I) editing and editing-independent mechanisms, ADAR1 suppresses activation of dsRNA sensing pathways, including protein kinase R (PKR), melano...

Carolyn N. Ashley, Emmanuel Broni, Chanyah M. Wood et al. · 0 citations

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