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Author

Chao Guan

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Review Open access Oct 2026

Compartment-specific m7G RNA modification in cancer: mechanisms, tumor adaptation, and therapeutic vulnerabilities

N7-methylguanosine (m 7 G) is distributed across several RNA classes and regulates distinct stages of gene expression. The best-characterized form is the 5′cap of messenger RNA, although m 7 G also occurs in transfer RNA, ribosomal RNA, internal messenger RNA, circular RNA, and transfer RNA-derived small RNAs. Ca...

Xiao-Xiao Tian, Di Huang, Chao Guan · 0 citations
Review Open access Sep 2026

RNA m6A modification-regulated ferroptosis in cancer: mechanism and therapeutic potential

Empirical evidence elucidating how m6A regulators remodel cystine import, GPX4-dependent antioxidant defense, FSP1 signaling, lipid metabolism, iron handling, autophagy and tumor-microenvironmental communication is synthesized.

Qing-Miao Shi, Yang-Ni Li, Chao Guan · 0 citations

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