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Open access Aug 2026

JP1 peptide modulates oxidative stress and autophagy via Keap1-Nrf2-ARE in ALS model mice

The simultaneous modulation of oxidative stress and autophagy represents a potential therapeutic strategy for amyotrophic lateral sclerosis (ALS), yet agents capable of coordinately regulating both processes remain scarce. The Keap1‑Nrf2‑ARE pathway serves as a critical hub linking redox homeostasis and autophagic regu...

Yu Zhang, Yaxi Liu, Shiyu Shi et al. · 0 citations
Sep 2026

Hippocampal Caspase-4 non-canonical inflammasome activation is associated with microglia-synapse crosstalk disruption and drives depression-like behaviors.

Whether hippocampal non-canonical inflammasome activation drives microglial neuroinflammation and impairs synaptic plasticity to precipitate depression-like behavior and Targeting the Caspase-4 non-canonical inflammasome warrants further investigation as a potential, may offer a novel immunotherapeutic strategy for dep...

Chao Lu, Yan-Qing Wang, Guo-Liang Dai et al. · 0 citations

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