FGF21 inhibits atherosclerosis by reducing endothelial ferroptosis via activation of AMPK/Nrf2 signaling.
BACKGROUND Atherosclerosis is a chronic vascular disease characterized by endothelial dysfunction and lipid accumulation. Ferroptosis, an iron-dependent form of regulated cell death characterized by excessive lipid peroxidation, plays a pivotal role in endothelial injury and the progression of atherosclerosis. Fibrobla...