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Chao-Ren Shen

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Sep 2026

Chiral Arylthiol-Catalyzed Asymmetric Hydrodifluoroalkylation of Alkenes Facilitated by Noncovalent Interaction.

Chiral gem-difluorinated indane scaffolds are valuable fluorinated bioisosteres of medicinally important CH2-containing indane frameworks. Herein, a photodriven enantioselective hydrodifluoroalkylation of methyleneindanes with α-bromodifluoroamides catalyzed by a C2-symmetric chiral arylthiol was developed. This protoc...

Jing Wang, Chao-Ren Shen, Guang-Mang Wang et al. · 0 citations

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