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Open access Aug 2026

Negative allosteric regulation of protein arginine methyltransferase 1 (PRMT1) through half-of-sites reactivity

Protein arginine methyltransferase 1 (PRMT1) activity is essential for maintaining proper eukaryotic cellular function; however, its dysregulation contributes to the progression of several human diseases and cancers, making PRMT1 an attractive therapeutic target. Efforts to inhibit PRMT1 through active-site-directed co...

Vincent Rossi, Robert S. Wilson-Kovacs, Yuan Gao et al. · 0 citations
Review Jul 2026

Decoding Cardiovascular Disease Through Spatial Proteomics.

Cardiovascular function is tightly linked to tissue architectures, where the spatial organization of cells, extracellular matrix (ECM), vascular networks, and remodeling processes governs physiological performance and disease progression. Spatial proteomics has, therefore, emerged as a powerful framework for understand...

Min Ma, Yingyi Lian, Erfei Shang et al. · 0 citations

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