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Author

Chao Zhong

2 papers indexed here

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Open access Aug 2026

A Tumor-Microenvironment-Responsive Chemically Masked IL‑2 Prodrug Potentiates PD‑1 Checkpoint Blockade and Elicits Robust Antitumor Efficacy

Interleukin-2 (IL-2) is a potent mediator of T-cell activation with significant potential for cancer immunotherapy, yet its clinical utility is severely constrained by its narrow therapeutic window. Here we report a chemically masked IL-2 prodrug (Cm-proIL2) that enables tumor-microenvironment-responsive cytokine activ...

Linzhi Tan, Yuning Yang, Ke-Rui Zhao et al. · 0 citations
Review Open access Aug 2026

Multi‐omics–driven precision medicine

The value of MODPM lies not in stacking additional data layers but in building a multiscale, continuously learnable framework to link biological heterogeneity to clinically interpretable and actionable decisions.

Hui-Bo Li, Zhe Zhao, Yi-Fan Zhang et al. · 0 citations

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