Aug 2026
Microglial RIOK3 promotes post-ischemic neuroinflammation by facilitating YBX1 phosphorylation and nuclear accumulation.
Microglia-targeted RIOK3 knockdown reduced infarct volume, improved early neurological and sensorimotor outcomes, preserved microglial process complexity, and reduced post-ischemic inflammation, and highlight the RIOK-YBX1 axis as a potential therapeutic target for ischemic stroke.
Yang Geng, Ningning Zong, Chao Zhou et al.
· Experimental Neurology · 0 citations