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Charan Pithana Sai Venkata Vijay

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Review Open access Nov 2026

DNA Repair Pathways as Determinants of PARP Inhibitor Resistance and Therapeutic Targets in Cancer

Poly (ADP-ribose) polymerase inhibitors (PARPi) have transformed the treatment landscape for homologous recombination-deficient (HRD) cancers, particularly those harboring BRCA1/2 mutations, including breast, ovarian, prostate, and pancreatic cancers, by exploiting the synthetic lethality induced by HR deficiency (HRD)...

Kousalya Lavudi, M. Renjith, Charan Pithana Sai Venkata Vijay et al. · 0 citations

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