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Author

Charbel Alfeghaly

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Open access Oct 2026

XIST drives X-chromosome inactivation and safeguards female extraembryonic cells in humans

X-chromosome inactivation (XCI) is essential for extraembryonic tissue growth and embryo development in mice. However, species-specific differences in its timing and regulation have left its role in human development unclear. Here, we show that the in vitro differentiation of naive human pluripotent stem cells to troph...

Amitesh Panda, L. Carrillo, B. Balaton et al. · 1 citation
Open access Jul 2026

Netrin-1 Acts as a Guardian of Naive Pluripotency in Human Embryonic Stem Cells

The role of Netrin-1 is identified as a coordinator of extracellular cues, intracellular signaling, and nuclear regulatory mechanisms that support human naïve pluripotency.

Agathe de Neufville, Etienne Masfaraud, Charbel Alfeghaly et al. · 0 citations

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