Open access
Jul 2026
IL-1β/IL-6 signaling circuit in the tumor microenvironment drives prostate cancer development
A pro-tumorigenic IL-1β/IL-6 signaling circuit mediated through local macrophages and fibroblasts is identified that unleashes the full oncogenic potential of a cancer driver activated at the PIN stage, with implications for TME-specific targeted therapeutics in early-stage disease.
Young-Sun Lee, Jimmy L. Zhao, Agnieszka Chryplewicz et al.
· bioRxiv · 0 citations