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Author

Charles Yeaman

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Open access Oct 2026

Ncf1/Igfbp2 Signaling Regulates Airway Submucosal Gland Progenitor Fitness and Ionocyte Specification

Background Airway submucosal gland progenitors (SMGPs) serve as reserve stem cells for epithelial regeneration, yet mechanisms governing their long-term maintenance remain poorly understood. Here, we identify Ncf1/Igfbp2 signaling as a regulator of mouse SMGP fitness and epithelial lineage specification. Methods Mouse...

Javahir Hajibabazade, K. Campbell, O. Atanda et al. · 0 citations
Open access Oct 2026

Lef1 Promotes Foxi1-Dependent Ionocyte Specification by Airway Submucosal Gland Progenitors

Pulmonary ionocytes are rare cells in submucosal gland (SMG)–containing airways thought to have specialized ion transport properties that regulate airway surface fluid and mucus composition. The origins of pulmonary ionocytes remain unclear, but their association with airway SMGs suggests they may arise from specialize...

Weam S. Shahin, Javahir Hajibabazade, Olivia Snyder et al. · 0 citations

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