Review
Open access
Aug 2026
Iron regulation by Sirtuins 1 & 2 and their therapeutic modulation by Sirtinol
Sirtuins 1 & 2 (SIRTs 1 & 2) are deacetylases that are overexpressed in several types of cancer, thereby contributing to various hallmarks of cancer, such as increased proliferation and chemoresistance. Therefore, these enzymes represent potential therapeutic targets. Sirtinol is a small-molecule pharmacological inhibi...
Koffi Amegble, Lu-Jia Liu, To-Ni Q. Duan et al.
· Frontiers in Pharmacology · 0 citations