Author

Chawon Yun

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Review Open access Aug 2026

Peripheral Nerve Injury and Denervation-Induced Sarcopenia with a Focus on Pharmacological Dual-Target Strategies

Peripheral nerve injury (PNI) causes rapid disruption of neuromuscular connectivity, leading to sarcopenia characterized by muscle wasting, mitochondrial dysfunction, and metabolic imbalance. Although calcium dysregulation and aberrant AMPK/mTOR signaling are known contributors, the molecular cascade linking nerve inju...

Chawon Yun, J. Won, So-Young Lee et al. · Biomolecules & Therapeutics · 0 citations

Open access Jul 2026

TRIM21 Orchestrates Inflammasome Assembly and Drives Autoinflammatory Pathology 2300561

Inflammasomes are pivotal cytoplasmic scaffolds that drive the maturation of interleukin (IL)-1β and IL-18 and initiate pyroptotic cell death. Tight regulation of inflammasome activity is critical, as uncontrolled IL-1β release underlies chronic inflammation and autoinflammatory disease. The adaptor protein ASC i...

Jessica Carriere, Chawon Yun, Sonal Khare et al. · Journal of Immunology · 0 citations

Open access Aug 2026

Stage-dependent doxorubicin toxicity impairs C2C12 myogenesis via AMPK/AKT-FOXO signaling and is attenuated by metformin.

Doxorubicin (DOX) can compromise skeletal muscle, but whether toxicity depends on myogenic stage is unclear. C2C12 myoblasts were exposed to non‑cytotoxic DOX (0.025-0.1μg/mL) before differentiation (24h) or after 3 days of differentiation (48h), with or without metformin (Met; 0.1-2mM). Pre‑differentiation DOX markedl...

S. Kim, C. Ryu, Chawon Yun et al. · Environmental Toxicology and... · 0 citations