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Divergent Roles of PIK3C3 in KRAS‐Wild‐Type and KRAS‐Mutant Advanced Colorectal Cancer: Implications for 5‐Fluorouracil Sensitivity and Prognosis
ABSTRACT Introduction Phosphatidylinositol 3‐kinase catalytic subunit type 3 (PIK3C3) is central to autophagy, which supports cancer adaptation to environmental stresses and may contribute to drug resistance. KRAS‐mutant cancers have been reported to require autophagy for survival. We investigated the influence of KRAS...