Author

Chen-Bo Huang

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Open access Oct 2026

A multi-omics study integrating single-cell transcriptomics, spatial transcriptomics, and mendelian randomization unveil the implication of TRDMT1 expression in T cells on the immunotherapeutic response and prognosis in breast cancer

Mendelian randomization analysis indicated that the expression of the m5C writer tRNA aspartate methyltransferase 1 (TRDMT1) in blood was associated with breast cancer prognosis, and the immunotherapy predict value and prognostic value of measuring TRDMT1 levels in CD8+ T cells were confirmed.

Ting-Jun Li, Chen-Bo Huang, Hao-Lan Deng et al. · Functional & Integrative Gen... · 0 citations

Open access Aug 2026

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

This work identifies alanyl tRNA synthetase 1 (AARS1) as a clinically relevant driver of aggressive and recurrent BC and defines an AARS1 associated metabolic and epigenetic program in BC and nominate AARS1 targeting strategies as a direction for further therapeutic development.

Qin Yuan, Tianbao Song, Yipeng He et al. · Advancement of science · 0 citations