Heart failure (HF) remains a leading cause of morbidity and mortality worldwide. A hallmark of HF progression is profound metabolic remodeling accompanied by mitochondrial dysfunction in cardiomyocytes. Impaired mitochondrial oxidative phosphorylation, excessive reactive oxygen species (ROS) production, and disrupted r...
This review provides an integrated and conceptual analysis of the HCC immune landscape, delineating the mechanistic drivers underlying immune suppression, summarizes current immune-based classification frameworks, and dissects the context-dependent functions of key immune cell populations in tumor progression.
Jia-Qian Zhang, Si-Wen Li, Xiang-Long Ma et al.· Cancer Biology and Medicine· 0 citations
Coronary artery disease (CAD) is a typical age-related chronic condition, with its development and progression spanning a long course of life and exhibiting significant inter-individual heterogeneity. Traditional risk assessment models based on chronological age and single risk factors are often insufficient to capture...
Ru Sun, Weijian Hang, Ling Zhou et al.· International Journal of Dru...· 0 citations
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