Palladium-catalyzed cascade imidoylative Heck annulation of functionalized isocyanides for the construction of 1,4-diazepinones.
A palladium-catalyzed cascade imidoylative/Heck annulation of functionalized isocyanides is reported, providing convenient and efficient access to 1,4-diazepinones bearing an exocyclic alkene. Using readily available alkene-tethered isocyanides and aryl iodides as starting materials, this protocol delivers a range of s...