Open access
Aug 2026
DYNAMIC CONFORMATIONS IN THE ACTIVATION OF PINK1 KINASE
Under mitochondrial stress, the mitochondrial kinase PINK1 is activated to phosphorylate ubiquitin, which in turn recruits the E3 ligase Parkin, thereby initiating clearance of damaged mitochondria. Dysregulation of the PINK1–Parkin signaling pathway is associated with early- onset autosomal recessive Parkinson’s disea...
Huiqin Xu, Xin-Yang Liu, Yan Jiang et al.
· bioRxiv · 0 citations