Author

Chen-Meng Huang

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Open access Sep 2026

Levofloxacin enhances 5-fluorouracil efficacy in colorectal cancer by activating the DDR-TP53-mitochondrial apoptosis axis

Summary 5-Fluorouracil (5-FU)-based regimens are a cornerstone of colorectal cancer (CRC) chemotherapy. Levofloxacin (LVF), a widely used fluoroquinolone antibiotic, has been reported to exhibit anticancer properties. We investigated LVF’s ability to enhance CRC chemosensitivity to 5-FU in cell lines, subcutaneous xeno...

Chen-Meng Huang, Chen-Chen Sun, Han Wang et al. · iScience · 0 citations

Sep 2026

Multimethod-guided discovery of novel α-pyrone dimers with cardiomyocyte-protective activity against cold ischemia injury from the coral-derived Talaromyces sp. TJ403-AL05.

Guided by molecular networking, HSQC-based DeepSAT, and SMART analyses, a chemical investigation of the coral-derived fungus Talaromyces sp. TJ403-AL05 led to the isolation and identification of taladipyrones A-I (1-9), a series of new α-pyrone dimers with four distinct skeletons. Among these, compounds 1 and 9 represe...

Han-Xiao Zeng, Yaxing Wang, Chen-Meng Huang et al. · Chinese Journal of Natural M... · 0 citations