Chen-Ming Si

Rapamycin attenuates ferroptotic stress and improves macrophage efferocytosis in experimental atherosclerosis.

BACKGROUND Defective macrophage efferocytosis contributes to necrotic core formation and plaque instability in atherosclerosis. Ferroptosis and mitochondrial dysfunction have been implicated in macrophage injury, but whether ferroptosis-associated mitochondrial dysfunction contributes to impaired efferocytosis and whet...