NUP35 drives the Warburg effect and malignant progression in glioblastoma by regulating GCKR stability and HK2 activation.
BACKGROUND The Warburg effect drives glioblastoma (GBM) progression, but its upstream regulators remain unclear. This study investigated the role and mechanism of nucleoporin 35 (NUP35) in GBM glycolytic reprogramming. METHODS Public datasets, including The Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expressio...