Chen-Tong Mao

Perineural invasion is associated with an aggressive phenotype and reduced in vitro capecitabine sensitivity in colorectal cancer

Perineural invasion (PNI) is an aggressive biological feature of colorectal cancer (CRC) driven by active crosstalk between tumor cells, Schwann cells, and the neural microenvironment. Although PNI is associated with recurrence, distant metastasis, and chemoresistance, its pathologic diagnosis is constrained by sam...