Open access
Oct 2026
SIR2-mediated filament assembly activates the NLR-like protein Avs5 for bacterial antiviral defense.
Like mammalian nucleotide-binding and oligomerization domain receptors (NLRs), bacterial NLR-like proteins mediate antiviral defense. Avs5, a representative of a large family of short bacterial NLR-like proteins, contains an N-terminal SIR2 effector, a central nucleotide-binding domain (NBD), and a C-terminal sensor do...
Chen Wang, Jia-Le Xie, Zhang-Fei Shen et al.
· Cell Reports · 0 citations