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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Chen Weng

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Open access Aug 2026

Low-heteroplasmy mitochondrial DNA mutations improve clonal reconstruction of human cells

Reconstructing clonal relationships among human cells is fundamental to understanding development, aging, and disease. Somatic mitochondrial DNA (mtDNA) mutations act as endogenous single-cell barcodes measurable alongside cell-state profiles, but lineage tracing has traditionally focused on high-heteroplasmy variants,...

Chen Weng, T. Gao, William N. Colgan et al. · 0 citations
Open access Aug 2026

A functional genomics screen of human B-cell differentiation reveals convergent mechanisms of inherited childhood leukemia predisposition

B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer, yet the mechanisms by which inherited risk variants predispose to leukemia development remain poorly understood. A major challenge to studying these mechanisms has been the lack of model systems that faithfully capture the transient develo...

Lara Wahlster, Anna-Lena Neehus, Andrew J. Lee et al. · 0 citations

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