Author

Chen Wu

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Open access Jul 2026

RNA exonuclease REXO4 resolves m6A-marked R-loops and suppresses anti-tumor immunity.

Transcription blockage frequently occurs in tumor cells, and aberrant R-loop formation during this process drives genome instability. However, the regulation of R-loop homeostasis and its contribution to tumorigenesis remain to be investigated. Here, we report that the RNA exonuclease REXO4 resolves R-loops by 3'-5' ex...

Jieyou Zhang, Kaiwen Bao, Yayan Hou et al. · Molecules and Cells · 0 citations

Open access Aug 2026

HDGF induces inflammatory cancer-associated fibroblast formation through ENO1-mediated glycolytic reprogramming in esophageal squamous-cell carcinoma.

An HDGF/ENO1/H4K12la/iCAF axis that links tumor metabolic reprogramming, stromal inflammatory activation, and immunosuppression in ESCC is revealed, identifying this axis as a promising therapeutic target for overcoming immunotherapy resistance.

Zhengqing Song, Cai-Nan Li, Pujie Wu et al. · Cancer Letters · 0 citations