Open access
Oct 2026
NOTCH1 and ADORA3 define a novel transdifferentiation-related prognostic index for prognostic stratification in glioblastoma by integrating clinical factors.
BACKGROUND/OBJECTIVES Glioblastoma (GBM) exhibits aggressive progression and poor prognosis, partly driven by glioma stem cell-endothelial transdifferentiation (GSC-ET), an alternative vascularization mechanism associated with therapeutic resistance. However, robust prognostic models based on transdifferentiation-relat...
Zong-Qing Zheng, Yi-Xiao Li, Yong-Xiang Zhang et al.
· Brain Research Bulletin · 0 citations